Papuacerdrus papuana (f. Muell) h.l.li., A NEW SOURCE FOR TWO BIOACTIVE DITERPENES OF FERRUGINOL AND trans-COMMUNIC ACID THAT VIRTUALLY ACTIVE AGAINST SARS-COV-2

 
 
Penulis:
The aim of the study is the research and identification of bioactive secondary metabolites from the leaves of Papuacedrus papuana that not have been reported yet so far. Two main antibacterial compounds ferruginol and trans-communic acid were isolated from the leaves of the plant through several chromatography techniques, including a TLC-direct bioautography technique. The antibacterial activity of abiatane and labdane diterpenes was categorized as with the values of MIC were 16 and 4 µg/mL for ferruginol and 8 and 16 for trans-cummunic acid against Escherichia coli InaCC B5 and Staphylococcus aureus InaCC B4, respectively. In addition, only ferruginol showed a moderate antioxidant activity with an IC50 value of 116.12 μg/mL. By docking studies, both compounds were showing their more stable interaction with structural SARS-CoV-2 proteins, ie. 6vxx Spike glycoprotein and 6m0j spike receptor compare to non-structural proteins such as 3CLpro, Mpro, RdRp proteases. Keywords: Papuacedrus papuana, diterpene, ferruginol, trans-communic acid, antibacterial, antioxidant, anti-SARS-CoV-2.

Rasayan journal of Chemistry vol. 15, no. 2

No. Arsip : LIPI-20220121